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BDBM284419 4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyridin-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10023570, Example 429::US10174028, Example 429

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N

InChI Key: InChIKey=IUFZQQYNEYFNFB-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284419   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.10n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.9n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.10n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284419
PNG
(4-(6-(4-(2,5- difluorobenzyl)piperazin- 1-yl)pyrid...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3cc(F)ccc3F)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H24F2N8/c1-35-16-23(15-33-35)20-11-25(28-22(12-31)14-34-38(28)18-20)19-2-5-27(32-13-19)37-8-6-36(7-9-37)17-21-10-24(29)3-4-26(21)30/h2-5,10-11,13-16,18H,6-9,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.10n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair