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BDBM284441 4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10023570, Example 451::US10174028, Example 451

SMILES: COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key: InChIKey=BQBXBVMCLBDWIT-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284441   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.7n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284441
PNG
(4-(6-(4-(2- methoxybenzyl)piperazin- 1-yl)pyridin-...)
Show SMILES COc1ccccc1CN1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1
Show InChI InChI=1S/C29H28N8O/c1-34-18-25(17-32-34)23-13-26(29-24(14-30)16-33-37(29)20-23)21-7-8-28(31-15-21)36-11-9-35(10-12-36)19-22-5-3-4-6-27(22)38-2/h3-8,13,15-18,20H,9-12,19H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair