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BDBM284511 US10023570, Example 524::US10174027, Example 524::tert-butyl 2-(5-(3-cyano- 6-(1-methyl-1H-pyrazol- 4-yl)pyrazolo[1,5- a]pyridin-4-yl)pyridin-2- yl)-2,5- diazaspiro[3.4]octane-5- carboxylate

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N

InChI Key: InChIKey=FKGXOAOOSQCXBV-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284511   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 693n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 693n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 693n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284511
PNG
(US10023570, Example 524 | US10174027, Example 524 ...)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CC3(C2)CCCN3C(=O)OC(C)(C)C)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H30N8O2/c1-27(2,3)38-26(37)35-9-5-8-28(35)17-34(18-28)24-7-6-19(12-30-24)23-10-20(22-14-31-33(4)15-22)16-36-25(23)21(11-29)13-32-36/h6-7,10,12-16H,5,8-9,17-18H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 110n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair