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BDBM284648 US10023570, Example 683::US10174027, Example 683

SMILES: Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N

InChI Key: InChIKey=XIZVNYJPZIUDCK-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284648   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36.9n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 148n/an/an/an/a7.4n/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE -TK ...


US Patent US10023570 (2018)


BindingDB Entry DOI: 10.7270/Q2Q81G4V
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 148n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 148n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK a...


US Patent US10174028 (2019)


BindingDB Entry DOI: 10.7270/Q2PR7Z2J
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM284648
PNG
(US10023570, Example 683 | US10174027, Example 683)
Show SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(Cc3ccn(C)c(=O)c3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H27N9O/c1-33-6-5-20(11-27(33)38)17-35-7-9-36(10-8-35)26-4-3-21(14-30-26)25-12-22(24-16-31-34(2)18-24)19-37-28(25)23(13-29)15-32-37/h3-6,11-12,14-16,18-19H,7-10,17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 36.9n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK ...


US Patent US10174027 (2019)


BindingDB Entry DOI: 10.7270/Q2TH8PRD
More data for this
Ligand-Target Pair