BDBM28538 Azepino[4,5-b]indole, 6i::FXR_5::ethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1H,2H,3H,6H-azepino[4,5-b]indole-5-carboxylate

SMILES CCOC(=O)C1=CN(CC(C)(C)c2c1[nH]c1ccccc21)C(=O)c1ccc(F)c(F)c1

InChI Key InChIKey=NVFAURZVYMEWBH-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 28538   

TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataEC50:  12nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataEC50:  85nMAssay Description:Agonist activity at Gal4-fused human FXR by luciferase reporter gene transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataIC50:  21nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataIC50:  1.42E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In DepthDetails PubMed