BDBM287653 US10085984, Example 31::US11040034, Ex. No. 31

SMILES CCS(=O)(=O)NCc1cc(cnn1)-c1nc2ccc(F)cc2n1C1CC1

InChI Key InChIKey=NKVLQXHGVWWWBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287653   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287653(US10085984, Example 31 | US11040034, Ex. No. 31)
Affinity DataIC50: <100nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Phasebio Pharmaceuticals

US Patent
LigandPNGBDBM287653(US10085984, Example 31 | US11040034, Ex. No. 31)
Affinity DataIC50: >1.00E+4nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287653(US10085984, Example 31 | US11040034, Ex. No. 31)
Affinity DataIC50:  50nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Phasebio Pharmaceuticals

US Patent
LigandPNGBDBM287653(US10085984, Example 31 | US11040034, Ex. No. 31)
Affinity DataIC50: >1.00E+3nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent