BDBM289626 9-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methyl)-6-(4-methoxybenzyl)-8,9,10,11-tetrahydropyrido[4',3':4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5 (6H)-one::US10092575, Example 114::US10376514, Example 114

SMILES COc1ccc(Cn2c3sc4CN(Cc5ccc6OC(F)(F)Oc6c5)CCc4c3c3ncnn3c2=O)cc1

InChI Key InChIKey=ZXHSPMXDQPMINS-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 289626   

TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289626(9-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methyl)-6...)
Affinity DataIC50:  550nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289626(9-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methyl)-6...)
Affinity DataIC50:  550nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Dart Neuroscience (Cayman)

US Patent
LigandPNGBDBM289626(9-((2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methyl)-6...)
Affinity DataEC50:  550nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent