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BDBM292602 N-(2-(diethylamino)ethyl)-2-(3-hydroxy-3-methylazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 258

SMILES: CCN(CC)CCNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C)(O)C1

InChI Key: InChIKey=PYKGXDGMLGMCMB-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292602
PNG
(N-(2-(diethylamino)ethyl)-2-(3-hydroxy-3-methylaze...)
Show SMILES CCN(CC)CCNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C)(O)C1
Show InChI InChI=1S/C26H31N7O2S/c1-4-31(5-2)11-9-27-25(34)18-13-21(29-23(14-18)32-16-26(3,35)17-32)19-15-28-33-10-8-20(30-24(19)33)22-7-6-12-36-22/h6-8,10,12-15,35H,4-5,9,11,16-17H2,1-3H3,(H,27,34)
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 53.7n/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...


US Patent US10100058 (2018)


BindingDB Entry DOI: 10.7270/Q2V98B4F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM292602
PNG
(N-(2-(diethylamino)ethyl)-2-(3-hydroxy-3-methylaze...)
Show SMILES CCN(CC)CCNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C)(O)C1
Show InChI InChI=1S/C26H31N7O2S/c1-4-31(5-2)11-9-27-25(34)18-13-21(29-23(14-18)32-16-26(3,35)17-32)19-15-28-33-10-8-20(30-24(19)33)22-7-6-12-36-22/h6-8,10,12-15,35H,4-5,9,11,16-17H2,1-3H3,(H,27,34)
PDB

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KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.07n/an/an/an/an/an/a



Gilead Sciences Inc

US Patent


Assay Description
The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...


US Patent US10100058 (2018)


BindingDB Entry DOI: 10.7270/Q2V98B4F
More data for this
Ligand-Target Pair