BindingDB logo
myBDB logout

BDBM292741 US10106501, Example B-18

SMILES: Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CC5(CC(C5)C(O)=O)C4)c3Cl)cc12)C(F)(F)F

InChI Key: InChIKey=SZEWMEBFWNQVPK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292741   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292741
PNG
(US10106501, Example B-18)
Show SMILES Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CC5(CC(C5)C(O)=O)C4)c3Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C26H23Cl2F3N2O3/c1-13-5-15(26(29,30)31)6-21-18(13)7-16(32(21)2)8-19-20(27)4-3-17(22(19)28)23(34)33-11-25(12-33)9-14(10-25)24(35)36/h3-7,14H,8-12H2,1-2H3,(H,35,36)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair