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BDBM292746 US10106501, Example B-23

SMILES: Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CCC(CC4)C(C)(C)C(O)=O)c3Cl)cc12)C(F)(F)F

InChI Key: InChIKey=FNYHXAITGYZSDG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292746
PNG
(US10106501, Example B-23)
Show SMILES Cc1cc(cc2n(C)c(Cc3c(Cl)ccc(C(=O)N4CCC(CC4)C(C)(C)C(O)=O)c3Cl)cc12)C(F)(F)F
Show InChI InChI=1S/C28H29Cl2F3N2O3/c1-15-11-17(28(31,32)33)12-23-20(15)13-18(34(23)4)14-21-22(29)6-5-19(24(21)30)25(36)35-9-7-16(8-10-35)27(2,3)26(37)38/h5-6,11-13,16H,7-10,14H2,1-4H3,(H,37,38)
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair