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BDBM292761 (2,4-dichloro-3-((3,7-dimethyl-5-(trifluoromethyl)-1H-indazol-1-yl)methyl)phenyl)(4-(oxetan-3-yl)piperidin-1-yl)methanone::US10106501, Example DD-1

SMILES: Cc1nn(Cc2c(Cl)ccc(C(=O)N3CCC(CC3)C3COC3)c2Cl)c2c(C)cc(cc12)C(F)(F)F

InChI Key: InChIKey=DYBNUJKKDSSNEH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292761   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292761
PNG
((2,4-dichloro-3-((3,7-dimethyl-5-(trifluoromethyl)...)
Show SMILES Cc1nn(Cc2c(Cl)ccc(C(=O)N3CCC(CC3)C3COC3)c2Cl)c2c(C)cc(cc12)C(F)(F)F
Show InChI InChI=1S/C26H26Cl2F3N3O2/c1-14-9-18(26(29,30)31)10-20-15(2)32-34(24(14)20)11-21-22(27)4-3-19(23(21)28)25(35)33-7-5-16(6-8-33)17-12-36-13-17/h3-4,9-10,16-17H,5-8,11-13H2,1-2H3
PDB

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UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair