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BDBM292799 US10106501, Example EJ-2

SMILES: Cc1cc(OC(F)(F)F)cc2ccn(Cc3c(Cl)ccc(C(=O)N4CCC(CCC(O)=O)CC4)c3Cl)c12

InChI Key: InChIKey=AFDWEWFEENHJIB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292799   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292799
PNG
(US10106501, Example EJ-2)
Show SMILES Cc1cc(OC(F)(F)F)cc2ccn(Cc3c(Cl)ccc(C(=O)N4CCC(CCC(O)=O)CC4)c3Cl)c12
Show InChI InChI=1S/C26H25Cl2F3N2O4/c1-15-12-18(37-26(29,30)31)13-17-8-11-33(24(15)17)14-20-21(27)4-3-19(23(20)28)25(36)32-9-6-16(7-10-32)2-5-22(34)35/h3-4,8,11-13,16H,2,5-7,9-10,14H2,1H3,(H,34,35)
PDB

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PC cid
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US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair