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BDBM292810 US10106501, Example ES

SMILES: Cc1cc(cc2ccn(C(=O)c3c(Cl)ccc(C(=O)N4CCC(CC(O)=O)CC4)c3Cl)c12)C(F)(F)F

InChI Key: InChIKey=CIUPEQBZTMBVLP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 292810   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM292810
PNG
(US10106501, Example ES)
Show SMILES Cc1cc(cc2ccn(C(=O)c3c(Cl)ccc(C(=O)N4CCC(CC(O)=O)CC4)c3Cl)c12)C(F)(F)F
Show InChI InChI=1S/C25H21Cl2F3N2O4/c1-13-10-16(25(28,29)30)12-15-6-9-32(22(13)15)24(36)20-18(26)3-2-17(21(20)27)23(35)31-7-4-14(5-8-31)11-19(33)34/h2-3,6,9-10,12,14H,4-5,7-8,11H2,1H3,(H,33,34)
PDB

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PC cid
PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...


US Patent US10106501 (2018)


BindingDB Entry DOI: 10.7270/Q2G44SBV
More data for this
Ligand-Target Pair