BDBM294039 Process 1::US10106557, Compound 1

SMILES Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O

InChI Key InChIKey=FFBHFFJDDLITSX-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 294039   

TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  0.470nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  1.01nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  2.87nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent