BDBM2955 GW420867X::HBY1293::propan-2-yl (2S)-2-ethyl-7-fluoro-3-oxo-1,2,3,4-tetrahydroquinoxaline-1-carboxylate

SMILES CC[C@@H]1N(C(=O)OC(C)C)c2cc(F)ccc2NC1=O

InChI Key InChIKey=KELNNWMENBUHNS-NSHDSACASA-N

Data  2 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2955   

TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM2955(GW420867X | HBY1293 | propan-2-yl (2S)-2-ethyl-7-f...)
Affinity DataIC50:  45nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM2955(GW420867X | HBY1293 | propan-2-yl (2S)-2-ethyl-7-f...)
Affinity DataIC50:  179nMpH: 8.2 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair