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BDBM297519 US10118902, Example 21::US10584103, Example 21::{4-[4-(2-methoxy-phenyl)- piperidin-1-yl]-2-[1-(methyl- propyl-amino)-cyclopropyl]- quinazolin-6-yl}-methyl-propyl- amine

SMILES: CCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1(CC1)N(C)CCC

InChI Key: InChIKey=RHOCAWMHTLRULS-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 297519   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297519
PNG
(US10118902, Example 21 | US10584103, Example 21 | ...)
Show SMILES CCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1(CC1)N(C)CCC
Show InChI InChI=1S/C31H43N5O/c1-6-18-34(3)24-12-13-27-26(22-24)29(33-30(32-27)31(16-17-31)35(4)19-7-2)36-20-14-23(15-21-36)25-10-8-9-11-28(25)37-5/h8-13,22-23H,6-7,14-21H2,1-5H3
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...


US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297519
PNG
(US10118902, Example 21 | US10584103, Example 21 | ...)
Show SMILES CCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1(CC1)N(C)CCC
Show InChI InChI=1S/C31H43N5O/c1-6-18-34(3)24-12-13-27-26(22-24)29(33-30(32-27)31(16-17-31)35(4)19-7-2)36-20-14-23(15-21-36)25-10-8-9-11-28(25)37-5/h8-13,22-23H,6-7,14-21H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)


BindingDB Entry DOI: 10.7270/Q27946Q9
More data for this
Ligand-Target Pair