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BDBM297533 N-[4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-2-(1-methyl- cyclopropyl)-quinazolin-6-yl]- N,N',N'-trimethyl-ethane-1,2- diamine::US10118902, Example 35::US10584103, Example 35

SMILES: CN(C)CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1(C)CC1

InChI Key: InChIKey=ITFARRJXTGCTGV-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 297533   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297533
PNG
(N-[4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-...)
Show SMILES CN(C)CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1(C)CC1
Show InChI InChI=1S/C31H42N6/c1-31(14-15-31)30-32-27-11-10-24(35(4)21-20-34(2)3)22-26(27)29(33-30)37-18-12-23(13-19-37)25-8-5-6-9-28(25)36-16-7-17-36/h5-6,8-11,22-23H,7,12-21H2,1-4H3
PDB

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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...


US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297533
PNG
(N-[4-[4-(2-azetidin-1-yl-phenyl)- piperidin-1-yl]-...)
Show SMILES CN(C)CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N3CCC3)c2c1)C1(C)CC1
Show InChI InChI=1S/C31H42N6/c1-31(14-15-31)30-32-27-11-10-24(35(4)21-20-34(2)3)22-26(27)29(33-30)37-18-12-23(13-19-37)25-8-5-6-9-28(25)36-16-7-17-36/h5-6,8-11,22-23H,7,12-21H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)


BindingDB Entry DOI: 10.7270/Q27946Q9
More data for this
Ligand-Target Pair