BindingDB logo
myBDB logout

BDBM297643 (2-methoxy-ethyl)-{4-[4-(2- methoxy-phenyl)-piperidin-1-yl]- 2-phenyl-quinazolin-6-yl}- methyl-amine::US10118902, Example 145::US10584103, Example 145

SMILES: COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)-c1ccccc1

InChI Key: InChIKey=JUZKKEXJBIYYKF-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 297643   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297643
PNG
((2-methoxy-ethyl)-{4-[4-(2- methoxy-phenyl)-piperi...)
Show SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)-c1ccccc1
Show InChI InChI=1S/C30H34N4O2/c1-33(19-20-35-2)24-13-14-27-26(21-24)30(32-29(31-27)23-9-5-4-6-10-23)34-17-15-22(16-18-34)25-11-7-8-12-28(25)36-3/h4-14,21-22H,15-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 μL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 a...


US Patent US10584103 (2020)


BindingDB Entry DOI: 10.7270/Q2M90C36
More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM297643
PNG
((2-methoxy-ethyl)-{4-[4-(2- methoxy-phenyl)-piperi...)
Show SMILES COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)-c1ccccc1
Show InChI InChI=1S/C30H34N4O2/c1-33(19-20-35-2)24-13-14-27-26(21-24)30(32-29(31-27)23-9-5-4-6-10-23)34-17-15-22(16-18-34)25-11-7-8-12-28(25)36-3/h4-14,21-22H,15-20H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
NTSR1 (NTR1) CHO cells are plated in 20 uL of assay media containing Ham's F12 supplemented with 10% fetal bovine serum and 0.4 mg/mL G418 at a c...


US Patent US10118902 (2018)


BindingDB Entry DOI: 10.7270/Q27946Q9
More data for this
Ligand-Target Pair