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BDBM299754 4-[4-(5-amino-6- carbamoylpyridin- 2-yl)piperidin-1- yl]-N- (bicyclo[1.1.1]pent- 1-yl)-6-[(1- cyanocyclopropyl) methoxy]-1,3,5- triazine-2- carboxamide::US9593097, Example 122

SMILES: NC(=O)c1nc(ccc1N)C1CCN(CC1)c1nc(OCC2(CC2)C#N)nc(n1)C(=O)NC12CC(C1)C2

InChI Key: InChIKey=RWOIKKZBLFXIIJ-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299754   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299754
PNG
(4-[4-(5-amino-6- carbamoylpyridin- 2-yl)piperidin-...)
Show SMILES NC(=O)c1nc(ccc1N)C1CCN(CC1)c1nc(OCC2(CC2)C#N)nc(n1)C(=O)NC12CC(C1)C2
Show InChI InChI=1S/C25H29N9O3/c26-12-24(5-6-24)13-37-23-31-20(21(36)33-25-9-14(10-25)11-25)30-22(32-23)34-7-3-15(4-8-34)17-2-1-16(27)18(29-17)19(28)35/h1-2,14-15H,3-11,13,27H2,(H2,28,35)(H,33,36)
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US Patent
0.319n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...


US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair