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BDBM299815 4-[4-(5-amino-6- carbamoylpyridin- 2-yl)piperidin-1- yl]-6-[(trans-3- fluorocyclobutyl) methoxy]-N- (2,2,2- trifluoroethyl)- 1,3,5-triazine-2- carboxamide::US9593097, Example 185

SMILES: NC(=O)c1nc(ccc1N)C1CCN(CC1)c1nc(OC[C@H]2C[C@H](F)C2)nc(n1)C(=O)NCC(F)(F)F

InChI Key: InChIKey=LLOSTJKLRRADFG-AULYBMBSSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299815   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299815
PNG
(4-[4-(5-amino-6- carbamoylpyridin- 2-yl)piperidin-...)
Show SMILES NC(=O)c1nc(ccc1N)C1CCN(CC1)c1nc(OC[C@H]2C[C@H](F)C2)nc(n1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H26F4N8O3/c23-13-7-11(8-13)9-37-21-32-18(19(36)29-10-22(24,25)26)31-20(33-21)34-5-3-12(4-6-34)15-2-1-14(27)16(30-15)17(28)35/h1-2,11-13H,3-10,27H2,(H2,28,35)(H,29,36)/t11-,13-
PDB

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US Patent
2.38n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...


US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair