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BDBM299873 6-(4-{[(4- aminopyrimidin-5- yl)oxy]methyl} piperidin-1- yl)-2-[(1- cyanocyclopropyl) methoxy]-N-(2,2- difluoropropyl) pyrimidine-4- carboxamide::US9593097, Example 243

SMILES: CC(F)(F)CNC(=O)c1cc(nc(OCC2(CC2)C#N)n1)N1CCC(COc2cncnc2N)CC1

InChI Key: InChIKey=CRFJRKJTCSCPEL-UHFFFAOYSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299873   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299873
PNG
(6-(4-{[(4- aminopyrimidin-5- yl)oxy]methyl} piperi...)
Show SMILES CC(F)(F)CNC(=O)c1cc(nc(OCC2(CC2)C#N)n1)N1CCC(COc2cncnc2N)CC1
Show InChI InChI=1S/C23H28F2N8O3/c1-22(24,25)12-29-20(34)16-8-18(32-21(31-16)36-13-23(11-26)4-5-23)33-6-2-15(3-7-33)10-35-17-9-28-14-30-19(17)27/h8-9,14-15H,2-7,10,12-13H2,1H3,(H,29,34)(H2,27,28,30)
PDB

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PC sid
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US Patent
9.34n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...


US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair