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BDBM299984 3-amino-6- (1-{2-[(1- cyanocyclopropyl) methoxy]-6-[(3,3- dimethylazetidin-1- yl)carbonyl] pyrimidin- 4-yl}piperidin- 4-yl)pyridine-2- carboxamide::US9593097, Example 355

SMILES: CC1(C)CN(C1)C(=O)c1cc(nc(OCC2(CC2)C#N)n1)N1CCC(CC1)c1ccc(N)c(n1)C(N)=O

InChI Key: InChIKey=LUFHNTDBEKGIPA-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299984   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM299984
PNG
(3-amino-6- (1-{2-[(1- cyanocyclopropyl) methoxy]-6...)
Show SMILES CC1(C)CN(C1)C(=O)c1cc(nc(OCC2(CC2)C#N)n1)N1CCC(CC1)c1ccc(N)c(n1)C(N)=O
Show InChI InChI=1S/C26H32N8O3/c1-25(2)13-34(14-25)23(36)19-11-20(32-24(31-19)37-15-26(12-27)7-8-26)33-9-5-16(6-10-33)18-4-3-17(28)21(30-18)22(29)35/h3-4,11,16H,5-10,13-15,28H2,1-2H3,(H2,29,35)
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US Patent
6.13n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...


US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair