BDBM300688 4-(methoxymethyl)-N-[5-(2- methylphenyl)-1,3,4-thiadiazol- 2-yl]-3-({[1-(4-methylpiperazin- 1-yl)cyclopropyl]carbonyl} amino)benzamide trifluoroacetate (1:1)::US10130633, Example 258

SMILES COCc1ccc(cc1NC(=O)C1(CC1)N1CCN(C)CC1)C(=O)Nc1nnc(s1)-c1ccccc1C

InChI Key InChIKey=BWPANBDMTCMGJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 300688   

TargetProtein Wnt-3a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300688(4-(methoxymethyl)-N-[5-(2- methylphenyl)-1,3,4-thi...)
Affinity DataIC50:  2.40E+4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein Wnt-3a(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300688(4-(methoxymethyl)-N-[5-(2- methylphenyl)-1,3,4-thi...)
Affinity DataIC50:  45.5nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent