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BDBM301369 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-morpholin-4-ylethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one::US10131667, Example 185::US9611267, Example 185

SMILES: CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F

InChI Key: InChIKey=HHGBASPZCGVBLW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 301369   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US10131667 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XJ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent




US Patent US10131667 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XJ1
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)


BindingDB Entry DOI: 10.7270/Q2N87CVP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)


BindingDB Entry DOI: 10.7270/Q2N87CVP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...


US Patent US9611267 (2017)


BindingDB Entry DOI: 10.7270/Q2N87CVP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM301369
PNG
(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(2-...)
Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CCN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C25H29F2N5O4/c1-4-31-22-15(13-28-24-17(22)11-16(29-24)5-6-30-7-9-36-10-8-30)14-32(25(31)33)23-20(26)18(34-2)12-19(35-3)21(23)27/h11-13H,4-10,14H2,1-3H3,(H,28,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent




US Patent US10131667 (2018)


BindingDB Entry DOI: 10.7270/Q2DR2XJ1
More data for this
Ligand-Target Pair