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BDBM302093 US9598415, 9

SMILES: CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n(C(C)C)c2=O)-c2c(OC)ncnc2C2CC2)nc1

InChI Key: InChIKey=FHDMUNWMIACNJV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302093   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM302093
PNG
(US9598415, 9)
Show SMILES CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n(C(C)C)c2=O)-c2c(OC)ncnc2C2CC2)nc1
Show InChI InChI=1S/C25H28N8O4S/c1-5-38(35,36)17-9-8-16(26-11-17)10-27-22-25(34)33(14(2)3)23-18(31-22)12-28-21(32-23)19-20(15-6-7-15)29-13-30-24(19)37-4/h8-9,11-15H,5-7,10H2,1-4H3,(H,27,31)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A nuclear receptor transactivation assay is performed to quantitate the ability of test compounds to inhibit RORγ transactivation of a luciferas...


US Patent US9598415 (2017)


BindingDB Entry DOI: 10.7270/Q2TQ63MW
More data for this
Ligand-Target Pair