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BDBM302266 US9598415, 178

SMILES: CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n(C(C)C)c2=O)-c2c(C)ncnc2C(C)C)nc1

InChI Key: InChIKey=NLRYCCNUDSEBIL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302266   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM302266
PNG
(US9598415, 178)
Show SMILES CCS(=O)(=O)c1ccc(CNc2nc3cnc(nc3n(C(C)C)c2=O)-c2c(C)ncnc2C(C)C)nc1
Show InChI InChI=1S/C25H30N8O3S/c1-7-37(35,36)18-9-8-17(26-11-18)10-27-23-25(34)33(15(4)5)24-19(31-23)12-28-22(32-24)20-16(6)29-13-30-21(20)14(2)3/h8-9,11-15H,7,10H2,1-6H3,(H,27,31)
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US Patent
n/an/a 240n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A nuclear receptor transactivation assay is performed to quantitate the ability of test compounds to inhibit RORγ transactivation of a luciferas...


US Patent US9598415 (2017)


BindingDB Entry DOI: 10.7270/Q2TQ63MW
More data for this
Ligand-Target Pair