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BDBM302322 US9598415, 234

SMILES: COc1ncnc(C2CC2)c1-c1ncc2nc(NCc3ccc(cn3)S(N)(=O)=O)c(=O)n(CC3CC3)c2n1

InChI Key: InChIKey=UANQAPJOBCANIV-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302322   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nuclear receptor ROR-gamma (RORC)


(Homo sapiens (Human))
BDBM302322
PNG
(US9598415, 234)
Show SMILES COc1ncnc(C2CC2)c1-c1ncc2nc(NCc3ccc(cn3)S(N)(=O)=O)c(=O)n(CC3CC3)c2n1
Show InChI InChI=1S/C24H25N9O4S/c1-37-23-18(19(14-4-5-14)29-12-30-23)20-28-10-17-22(32-20)33(11-13-2-3-13)24(34)21(31-17)27-8-15-6-7-16(9-26-15)38(25,35)36/h6-7,9-10,12-14H,2-5,8,11H2,1H3,(H,27,31)(H2,25,35,36)
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 590n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
A nuclear receptor transactivation assay is performed to quantitate the ability of test compounds to inhibit RORγ transactivation of a luciferas...


US Patent US9598415 (2017)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q2TQ63MW
More data for this
Ligand-Target Pair