BDBM304249 US10143695, Compound 55

SMILES COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3cc(C(=O)Nc4cc(C(=O)NCCCO)n(C)c4)n(C)c3)n(C)c1)N=C[C@H]1CC(=C)CN1C2=O

InChI Key InChIKey=MQUXLNNYYJDHRP-HHHXNRCGSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 304249   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mersana Therapeutics

US Patent
LigandPNGBDBM304249(US10143695, Compound 55)
Affinity DataIC50:  7.5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mersana Therapeutics

US Patent
LigandPNGBDBM304249(US10143695, Compound 55)
Affinity DataIC50:  2.5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mersana Therapeutics

US Patent
LigandPNGBDBM304249(US10143695, Compound 55)
Affinity DataIC50:  47nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-GloŽ (Promega...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mersana Therapeutics

US Patent
LigandPNGBDBM304249(US10143695, Compound 55)
Affinity DataIC50:  2nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mersana Therapeutics

US Patent
LigandPNGBDBM304249(US10143695, Compound 55)
Affinity DataIC50:  5nMAssay Description:PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent