BindingDB logo
myBDB logout

BDBM305021 4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin- 3-yl)-6-(2-hydroxy-2- methylpropoxy) pyrazolo[1,5-a] pyridine-3- carbonitrile::US10144734, Example 37::US10172845, Example 37::US10441581, Example 37

SMILES: CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N

InChI Key: InChIKey=PVUKUQAKWQGMTR-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 305021   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.3n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 39.3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM305021
PNG
(4-(6-(4-(4- fluorophenoxy) piperidin-1-yl)pyridin-...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(CC2)Oc2ccc(F)cc2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C28H28FN5O3/c1-28(2,35)18-36-24-13-25(27-20(14-30)16-32-34(27)17-24)19-3-8-26(31-15-19)33-11-9-23(10-12-33)37-22-6-4-21(29)5-7-22/h3-8,13,15-17,23,35H,9-12,18H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair