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BDBM305385 6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyridin-2-yloxy)piperidin- 1-yl)pyridin-3- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10144734, Example 402::US10172845, Example 402::US10441581, Example 402

SMILES: CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1

InChI Key: InChIKey=JXEODWORCMMZBH-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 305385   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
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DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET Kinase (aa658-end)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 71n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 11.7n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.5n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305385
PNG
(6-(2-(1-methylazetidin-3- yl)ethoxy)-4-(6-(4- (pyr...)
Show SMILES CN1CC(CCOc2cc(-c3ccc(nc3)N3CCC(CC3)Oc3ccccn3)c3c(cnn3c2)C#N)C1
Show InChI InChI=1S/C29H31N7O2/c1-34-18-21(19-34)9-13-37-25-14-26(29-23(15-30)17-33-36(29)20-25)22-5-6-27(32-16-22)35-11-7-24(8-12-35)38-28-4-2-3-10-31-28/h2-6,10,14,16-17,20-21,24H,7-9,11-13,18-19H2,1H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 18.5n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair