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BDBM305730 4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl)pyridin-3-yl)-6-(2- hydroxy-2- methylpropoxy) pyrazolo[1,5-a] pyridine-3-carbonitrile::US10144734, Example 748::US10172845, Example 748::US10441581, Example 748

SMILES: CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N

InChI Key: InChIKey=FNPNCWGKZUVHGC-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 305730   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305730
PNG
(4-(6-(4-(4-fluorobenzyl)- 4-hydroxypiperidin-1- yl...)
Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(O)(Cc3ccc(F)cc3)CC2)c2c(cnn2c1)C#N
Show InChI InChI=1S/C29H30FN5O3/c1-28(2,36)19-38-24-13-25(27-22(15-31)17-33-35(27)18-24)21-5-8-26(32-16-21)34-11-9-29(37,10-12-34)14-20-3-6-23(30)7-4-20/h3-8,13,16-18,36-37H,9-12,14,19H2,1-2H3
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 81n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair