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BDBM305756 3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- a]pyridin-4-yl)pyrazin-2- yl)-4-methylpiperidin-4- yl)picolinamide::US10144734, Example 774::US10172845, Example 774::US10441581, Example 774

SMILES: CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N

InChI Key: InChIKey=AYOVWZSAPAEMLL-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 305756   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
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antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...


US Patent US10144734 (2018)


BindingDB Entry DOI: 10.7270/Q2251M8C
More data for this
Ligand-Target Pair
RET Kinase (aa 658-1114)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET kinase mutant (V804M)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET kinase mutant (G810R)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



Array Biopharma Inc.

US Patent


Assay Description
The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...


US Patent US10441581 (2019)


BindingDB Entry DOI: 10.7270/Q2DZ0BP3
More data for this
Ligand-Target Pair
RET Kinase (V804M) (aa658-end)


(Homo sapiens (Human))
BDBM305756
PNG
(3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...)
Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncccc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H25ClN8O2/c1-3-37-18-11-19(24-17(12-28)13-32-35(24)16-18)21-14-31-22(15-30-21)34-9-6-26(2,7-10-34)33-25(36)23-20(27)5-4-8-29-23/h4-5,8,11,13-16H,3,6-7,9-10H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/an/an/a



Array BioPharma Inc

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...


US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair