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BDBM305963 US10144742, Compound I-125

SMILES: CS(=O)(=O)N1CCN(CC1)c1nc2ccc(cc2nc1-c1ccccc1)C(=O)NCCCn1ccnc1

InChI Key: InChIKey=WQANFULNNAOVOM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 305963   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM305963
PNG
(US10144742, Compound I-125)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1nc2ccc(cc2nc1-c1ccccc1)C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C26H29N7O3S/c1-37(35,36)33-16-14-32(15-17-33)25-24(20-6-3-2-4-7-20)29-23-18-21(8-9-22(23)30-25)26(34)28-10-5-12-31-13-11-27-19-31/h2-4,6-9,11,13,18-19H,5,10,12,14-17H2,1H3,(H,28,34)
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US Patent
n/an/a 300n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)


BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair