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BDBM306024 US10144742, Compound I-186

SMILES: Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccncc1

InChI Key: InChIKey=IPFYHFBJWMDRSZ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306024   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306024
PNG
(US10144742, Compound I-186)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)N1CCC(CC1)c1ccncc1
Show InChI InChI=1S/C31H24F2N4O/c32-25-6-1-22(2-7-25)29-30(23-3-8-26(33)9-4-23)36-28-19-24(5-10-27(28)35-29)31(38)37-17-13-21(14-18-37)20-11-15-34-16-12-20/h1-12,15-16,19,21H,13-14,17-18H2
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.00E+3n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)


BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair