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BDBM306067 US10144742, Compound I-229

SMILES: Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ccncc1

InChI Key: InChIKey=NUMSZVQBTCXKGU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306067   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306067
PNG
(US10144742, Compound I-229)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ccncc1
Show InChI InChI=1S/C29H22F2N4O/c30-23-8-3-20(4-9-23)27-28(21-5-10-24(31)11-6-21)35-26-18-22(7-12-25(26)34-27)29(36)33-15-1-2-19-13-16-32-17-14-19/h3-14,16-18H,1-2,15H2,(H,33,36)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 300n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)


BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair