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BDBM306140 US10144742, Compound I-302

SMILES: Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCc1cnc2ccccn12

InChI Key: InChIKey=DZZQYOYJRAHYBM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306140   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM306140
PNG
(US10144742, Compound I-302)
Show SMILES Fc1ccc(cc1)-c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCc1cnc2ccccn12
Show InChI InChI=1S/C30H21F2N5O/c31-22-9-4-19(5-10-22)28-29(20-6-11-23(32)12-7-20)36-26-17-21(8-13-25(26)35-28)30(38)33-15-14-24-18-34-27-3-1-2-16-37(24)27/h1-13,16-18H,14-15H2,(H,33,38)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 750n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3 final concentration wi...


US Patent US10144742 (2018)


BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair