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BDBM307764 N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N-methyl-N-phenylpropane-1,3-diamine::US9650358, Example 60

SMILES: CN(CCCNc1cc(c(Cl)cn1)-c1ccc2ncn(Cc3cccc(F)c3)c2c1)c1ccccc1

InChI Key: InChIKey=XFEVLIYGFMIONF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307764   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM307764
PNG
( N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzi...)
Show SMILES CN(CCCNc1cc(c(Cl)cn1)-c1ccc2ncn(Cc3cccc(F)c3)c2c1)c1ccccc1
Show InChI InChI=1S/C29H27ClFN5/c1-35(24-9-3-2-4-10-24)14-6-13-32-29-17-25(26(30)18-33-29)22-11-12-27-28(16-22)36(20-34-27)19-21-7-5-8-23(31)15-21/h2-5,7-12,15-18,20H,6,13-14,19H2,1H3,(H,32,33)
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US Patent
n/an/a 390n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9650358 (2017)


BindingDB Entry DOI: 10.7270/Q2057J0M
More data for this
Ligand-Target Pair