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BDBM307884 N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-7-(methylsulfonyl)-7-azaspiro[3.5]nonan-2-amine::US9650358, Example 180

SMILES: CS(=O)(=O)N1CCC2(CC(C2)Nc2cc(c(Cl)cn2)-c2ccc3ncn(CC4CCOCC4)c3c2)CC1

InChI Key: InChIKey=ICNNAHHOVFMSDX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM307884
PNG
(N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-...)
Show SMILES CS(=O)(=O)N1CCC2(CC(C2)Nc2cc(c(Cl)cn2)-c2ccc3ncn(CC4CCOCC4)c3c2)CC1
Show InChI InChI=1S/C27H34ClN5O3S/c1-37(34,35)33-8-6-27(7-9-33)14-21(15-27)31-26-13-22(23(28)16-29-26)20-2-3-24-25(12-20)32(18-30-24)17-19-4-10-36-11-5-19/h2-3,12-13,16,18-19,21H,4-11,14-15,17H2,1H3,(H,29,31)
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US Patent
n/an/a 180n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9650358 (2017)


BindingDB Entry DOI: 10.7270/Q2057J0M
More data for this
Ligand-Target Pair