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BDBM307981 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3,4-dihydro-2H-pyrano[2,3-b]pyridine-6-carboxamide::US9650358, Example 277

SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)c3cnc4OCCCc4c3)ncc2Cl)c1

InChI Key: InChIKey=YVWXTVYWJJAJHP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307981   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 9


(Homo sapiens (Human))
BDBM307981
PNG
(N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-...)
Show SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)c3cnc4OCCCc4c3)ncc2Cl)c1
Show InChI InChI=1S/C28H21ClFN5O2/c29-23-14-31-26(34-27(36)20-10-19-4-2-8-37-28(19)32-13-20)12-22(23)18-6-7-24-25(11-18)35(16-33-24)15-17-3-1-5-21(30)9-17/h1,3,5-7,9-14,16H,2,4,8,15H2,(H,31,34,36)
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US Patent
n/an/a 2.30E+3n/an/an/an/an/an/a



AbbVie Inc

US Patent


Assay Description
CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...


US Patent US9650358 (2017)


BindingDB Entry DOI: 10.7270/Q2057J0M
More data for this
Ligand-Target Pair