BDBM313482 3-(2-aminopropan-2-yl)- N-(3-(5-(3- hydroxyoxetan-3-yl)-6- methoxypyridin-3-yl)-4- methylphenyl)-5- (trifluoromethyl)benzamide::US10167279, Example 101

SMILES COc1ncc(cc1C1(O)COC1)-c1cc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(C)(C)N)ccc1C

InChI Key InChIKey=ZSGVRAZOFCAXHQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313482   

TargetSerine/threonine-protein kinase B-raf [416-766,V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313482(3-(2-aminopropan-2-yl)- N-(3-(5-(3- hydroxyoxetan-...)
Affinity DataIC50:  6.39E+3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313482(3-(2-aminopropan-2-yl)- N-(3-(5-(3- hydroxyoxetan-...)
Affinity DataIC50:  1.45E+3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent