BDBM315715 (S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(6- methoxy- pyridazin-3-yl)- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.12 (s,1H), 7.91 (d, J = 7.7, 1H), 7.69 (d, J = 9.2, 1H),7.66 (d, J = 9.5, 1H), 7.61-7.52 (m, 2H), 7.24-7.19 (m, 2H), 6.61 (d, J = 5.0, 1H), 6.23 (d,J = 4.9, 1H), 4.00 (s, 3H), 3.81-3.75 (m, 4H),3.48-3.43 (m, 4H)::US10172859, Example 136::US11065253, Example 136::US9732094, Example 136

SMILES COc1ccc(nn1)[C@@H](O)c1cc(c(F)cc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key InChIKey=MOWXJLUYGFNTAL-DEOSSOPVSA-N

Data  2 KI  3 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315715   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315715((S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quin...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315715((S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quin...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315715((S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quin...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315715((S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quin...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM315715((S)-[2-Chloro-4- fluoro-5-(7- morpholin-4-yl- quin...)
Affinity DataIC50: <3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair