BDBM31596 substituted pyrazole, 13

SMILES FC(F)(F)Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=NOIXNOMHHWGUTG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31596   

LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  1.41nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of rat PDE10AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM31596(substituted pyrazole, 13)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human PDE10A (amino acids 14 to 779) using [3H]-labelled cyclic nucleotide as substrate after 1 hr b beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed