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BDBM317258 US9617282, Example 27

SMILES: O=C1Nc2ccc(CCCN3CCCCC3)cc2OCCCCCNc2cc(ccn2)-c2nc1cs2

InChI Key: InChIKey=QZEABSWGMQPYEU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317258   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317258
PNG
(US9617282, Example 27)
Show SMILES O=C1Nc2ccc(CCCN3CCCCC3)cc2OCCCCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C28H35N5O2S/c34-27-24-20-36-28(32-24)22-11-13-30-26(19-22)29-12-3-1-6-17-35-25-18-21(9-10-23(25)31-27)8-7-16-33-14-4-2-5-15-33/h9-11,13,18-20H,1-8,12,14-17H2,(H,29,30)(H,31,34)
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)


BindingDB Entry DOI: 10.7270/Q2445PJK
More data for this
Ligand-Target Pair