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BDBM317342 US9617282, Example 115

SMILES: O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCN3CCNCC3)nc12

InChI Key: InChIKey=PIKICKQMSVAODF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317342   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317342
PNG
(US9617282, Example 115)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCN3CCNCC3)nc12
Show InChI InChI=1S/C23H28N8O4S/c32-21-18-15-36-23(28-18)16-1-2-25-19(13-16)35-12-11-34-10-5-26-22(33)20-17(27-21)14-31(29-20)9-8-30-6-3-24-4-7-30/h1-2,13-15,24H,3-12H2,(H,26,33)(H,27,32)
PDB
MMDB

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PC cid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)


BindingDB Entry DOI: 10.7270/Q2445PJK
More data for this
Ligand-Target Pair