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BDBM317343 US9617282, Example 116

SMILES: O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCN3CCCCC3)nc12

InChI Key: InChIKey=WRGGKBLCWRHKDM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317343   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317343
PNG
(US9617282, Example 116)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCN3CCCCC3)nc12
Show InChI InChI=1S/C24H29N7O4S/c32-22-19-16-36-24(28-19)17-4-5-25-20(14-17)35-13-12-34-11-6-26-23(33)21-18(27-22)15-31(29-21)10-9-30-7-2-1-3-8-30/h4-5,14-16H,1-3,6-13H2,(H,26,33)(H,27,32)
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MMDB

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PC cid
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US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)


BindingDB Entry DOI: 10.7270/Q2445PJK
More data for this
Ligand-Target Pair