BDBM318043 8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]piperazin- 1-yl]-3,5,6,7- tetrahydropyrido[2,3- d]pyrimidin-4-one::US9624218, Example 44

SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2nccnc2C)CC1

InChI Key InChIKey=WLVFPFBPOHXOMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318043   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318043(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Affinity DataIC50:  17.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318043(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Affinity DataIC50:  5.83E+3nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318043(8-Methyl-2-[4-[(3-methyl- pyrazin-2-yl)methyl]pipe...)
Affinity DataIC50:  12.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent