BDBM319015 N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluoropyridin-3- yl)-1,3- benzothiazol- 2-yl]-2- methanesulfonyl- acetamide::US10173991, Example 57
SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
InChI Key InChIKey=ZQLFQCLIZZQIPD-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 319015
Affinity DataIC50: 47nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human endothelial lipase using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20...More data for this Ligand-Target Pair