BDBM31915 CDV::Cidofovir::HPMPC::US10071110, Compound Cidofovir::Vistide

SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1

InChI Key InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

Data  6 IC50  1 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 31915   

Target2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase(Escherichia coli (strain K12))
University of Dundee

LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataKd:  4.00E+7nMpH: 7.0 T: 2°CAssay Description:An SPR assay was used to determine the binding affinities of compounds. Experiments were performed on a Biacore 3000 (Biacore, Uppsala, Sweden) instr...More data for this Ligand-Target Pair
TargetThymidine kinase(Macacine herpesvirus 1)
GLSynthesis Inc.

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 9.00E+5nMAssay Description:Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylationMore data for this Ligand-Target Pair
TargetHIV-1 protease(Human immunodeficiency virus)
The Regents of the University of California

US Patent
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataEC50:  1.20E+3nMAssay Description:Subconfluent MRC-5 cells in 24-well culture dishes were inoculated by removing the medium and adding HSV-1 virus at a dilution that will result in a ...More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 6.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM31915(CDV | Cidofovir | HPMPC | US10071110, Compound Cid...)
Show SMILES Nc1ccn(C[C@@H](CO)OCP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair