BindingDB logo
myBDB logout

BDBM325063 9-(4-(imidazo[1,2-a]pyridin-8-yl)benzyl)-2-(2-::US10189841, Compound I-269::US10399980, Compound I-269

SMILES: CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3cccn4ccnc34)c2n1

InChI Key: InChIKey=KCGVGLWMNZRQHD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 325063   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM325063
PNG
(9-(4-(imidazo[1,2-a]pyridin-8-yl)benzyl)-2-(2- | U...)
Show SMILES CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3cccn4ccnc34)c2n1
Show InChI InChI=1S/C29H26N6O/c1-19(2)22-7-4-5-8-24(22)26-31-17-25-28(32-26)35(29(36)33(25)3)18-20-10-12-21(13-11-20)23-9-6-15-34-16-14-30-27(23)34/h4-17,19H,18H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



FORMA Therapeutics, Inc.

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10399980 (2019)


BindingDB Entry DOI: 10.7270/Q23J3GCX
More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 1


(Homo sapiens (Human))
BDBM325063
PNG
(9-(4-(imidazo[1,2-a]pyridin-8-yl)benzyl)-2-(2- | U...)
Show SMILES CC(C)c1ccccc1-c1ncc2n(C)c(=O)n(Cc3ccc(cc3)-c3cccn4ccnc34)c2n1
Show InChI InChI=1S/C29H26N6O/c1-19(2)22-7-4-5-8-24(22)26-31-17-25-28(32-26)35(29(36)33(25)3)18-20-10-12-21(13-11-20)23-9-6-15-34-16-14-30-27(23)34/h4-17,19H,18H2,1-3H3
PDB

Reactome pathway

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Forma Therapeutics Inc

US Patent


Assay Description
The HTS assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning...


US Patent US10189841 (2019)


BindingDB Entry DOI: 10.7270/Q22R3TRR
More data for this
Ligand-Target Pair