BDBM325345 6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)-4-(l-(pentan-3- yl)-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyrazine::US10189845, Example 7::US10730880, Example 7::US11028093, Example 7

SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCCS(C)(=O)=O)c1

InChI Key InChIKey=DWXUDRWPYWVKRB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 325345   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM325345(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Affinity DataIC50:  5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent